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The International Day of Immunology celebrated on April 29th each year seeks to increase global awareness of the importance of immunology and its relevance in our fight against infectious diseases, autoimmunity, and cancer. The International Union of Immunological Societies (IUIS) and the European Federation of Immunological Societies (EFIS) working together with national and international societies to promote the benefits of immunology research around the world.
To mark the day, each year the ISI organise special events and activities which include the Annual Award recognising the work of outstanding immunologists in Ireland and Irish immunologists around the world.
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Sigita Malijauskaite

University of Limerick

Bernal Institute, University of Limerick, BioSciBER group.

Self-organizing “mini intestines”

Confocal Microscope Image

Grown from a single isolated intestinal stem cell, these organoids contain a variety of differentiated intestinal cell types. These organoids help us understand how inflammation affects intestinal development.

Claire Cuhningham

Trinity College Dublin

Molecular Rheumatology, School of Medicine, Trinity College Dublin, Dublin, Ireland

Contributors: Dr. V. Marzaioli, Dr. M. Hanlon, Dr. T. McGarry and Prof. U. Fearon. Molecular Rheumatology-TCD and CARD-UCD

Fibros on 
The Storm

Confocal Microscope Image

In Rheumatoid Arthritis, the synovium, which normally keeps joints healthy and lubricated, transforms into a hyperplastic aggressive pannus. Synovial fibroblasts, producing proinflammatory cytokines and metalloproteases, invade cartilage facilitating joint destruction.

Viviana Marzaioli

Trinity College Dublin & University College Dublin

Molecular Rheumatology & CARD - Trinity College Dublin & University College Dublin

Contributors: Dr. V. Marzaioli, Dr. M. Hanlon, Dr. T. McGarry and Prof. U. Fearon. Molecular Rheumatology-TCD and CARD-UCD


Transmission Electron Microscope Image

A circulating monocyte from a rheumatoid arthritis (RA) patient. Among the visible organelles are the smiling nucleus and the elongated mitochondria (fusion and/or fission), characteristic of a hyper-metabolic cell.

Mariana Cervantes

Lianne Shanley

Sinead O'Rourke

Royal College of Surgeons

School of Pharmacy and Biomolecular Sciences

Contributors: Mariana Cervantes, Sinead O' Rourke and Lianne Shanley - Curtis Clock Lab


Confocal Microscope Image

These are human macrophages under the confocal microscope showing a beautiful mitochondrial network stained in green and nuclei in red, representative image of fused mitochondrial morphology. These two macrophages have come together to form a heart shape.

Sarah Kuhn

Queen's University Belfast

Dombrowski Group

Mature Oligodendrocyte

Confocal Microscope Image

Oligodendrocytes are one of the main glial cells in the central nervous system, which have recently been shown to have potential immune cell-like properties as well.