Updated: Aug 10, 2021
This is an opportunity for a graduate level scientist to pursue cutting edge immunology research in a multidisciplinary research environment. The successful candidate will work on a Health Research Board funded project investigating how the microbiome composition impacts upon the immune response in the lungs of Chronic Obstructive Pulmonary Disease (COPD) patients.
COPD is the 3rd leading cause of death worldwide and affects over half a million people in Ireland. This respiratory condition causes difficulty breathing and irreversible damage to the lungs. COPD is an extremely debilitating condition for which there is only palliative treatment. Some patients experience flare-ups (exacerbations) which often causes hospitalisation and worsening of their condition, while others have a more stable pattern of disease. The reasons for these exacerbations are poorly understood.
Over the past decade a wealth of evidence have pointed at the human microbiota, a complex community of commensal microorganisms that colonise the mucosae and the skin, as a critical factor modulating human health and disease. The microbiome as emerged as an important factor influencing the response in the lungs during respiratory infections, asthma, allergy and is now emerging as a new element contributing to COPD. Here we will investigate how changes in the microbiome affect COPD progression and if shifts in the microbiome known as dysbiosis can contribute to COPD flare-ups. We will investigate how microbial-derived metabolites can help ease symptoms of COPD and restore the balance in the lungs.
The successful candidate will join the Translational Respiratory Immunology Lab (TRIL) https://www.respiratoryimmunology.com/ led by Res. Asst. Professor Natalia Muñoz-Wolf at the School of Medicine at Trinity College Dublin https://www.tcd.ie/medicine/ and the Department of Clinical Medicine at Tallaght university Hospital https://www.tuh.ie/Departments/The-Professorial-Respiratory-Centre/
Status: Accepting applications, submit your CV to firstname.lastname@example.org
Deadline: 20th September, 2021.
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