Project Title: Identifying novel aspects of immune checkpoint pathways to improve response rates in upper gastrointestinal cancer.
Project Description: Immune checkpoint inhibitors (ICI), the most successful form of immunotherapy, aims to restore T cell function by blocking immunosuppressive signals through immune checkpoint receptors (ICR), namely PD-1 and CTLA-4. However, there is a lack of accurate biomarkers of response or basis for patient selection for ICI therapy and all focus on the immunological response. We have identified the expression of ICR on upper gastrointestinal tumour cells and early studies have demonstrated that signalling through these ICR provide survival signals, reflective of the hallmarks of cancers. This novel project will investigate in detail the pro-tumourigenic roles of tumour cell-intrinsic ICR signalling, leading to the identification of targetable pathways essential for tumour cell survival and ultimately expand the relatively limited cohort of patients who currently benefit from immune checkpoint inhibitors.
Qualifications: A PhD in Cancer Immunology or a closely-related discipline is required.
Starting Date: 1st November 2021. This position is supported by a Science Foundation Ireland’s Frontiers for the Future Project Award to Dr. Joanne Lysaght.
To Apply: Applicants should submit a single PDF document containing a cover letter and full Curriculum Vitae to include the names and full contact details of 2-3 referees to: Dr. Joanne Lysaght, Email: email@example.com
Informal queries should be directed to Dr. Joanne Lysaght.
Status: Accepting applications.
Deadline: 4th October, 2021.
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