This is a postdoc position for up to three years working as part of a BBSRC funded research programme to characterise the fundamental biology of the inflammasome sensor NLRP3. Starting on or before 01/01/2022.
The project will investigate the temperature-dependent mechanisms of inflammasome regulation using a range of pharmacological and biochemical approaches. It will include the use of advanced quantitative mass spectrometry techniques in collaboration with Dr. Ben Collins at QUB; and it will also develop several cell-based models of the NLRP3 autoinflammatory disease Familial Cold Autoinflammatory Syndrome.
The Coll Lab is looking for a candidate with a background in immunology, biochemistry, or cell biology, with experience in techniques such as: culture of mouse and human primary myeloid cells, cell lines and iPSCs, innate immunity/inflammasome signalling assays, co-IP assays, proximity ligation assays, cellular thermal shift assays, immunofluorescence and confocal microscopy.
The applicant will benefit from the unique research environment at WWIEM that includes clinical and basic science expertise in eye disease, infectious diseases and respiratory disease, and access to state-of-the-art technologies. This is a supportive and inclusive workplace striving for excellence in experimental medicine.
Status: Accepting applications.
Deadline: 30th August, 2021.
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