Molecular Rheumatology, Trinity Biomedical Sciences Institute, TCD (https://rheumatologytcd.com) is seeking to appoint a Post-Doctoral Fellow (3 years) to perform research focused on examining the molecular and metabolic pathways that govern immune-stromal cell interactions in autoimmune diseases.
Project Summary: The objective of this project is to comprehensively investigate the molecular pathways that govern immune-stromal cell interactions in autoimmune diseases, specifically focusing on how these interactions define differential pathogenic mechanisms in Rheumatoid Arthritis and Psoriatic Arthritis. The project has a particular focus on how altered metabolic pathways control the fate and function of monocyte/macrophages lineages and how this impacts on their interaction with other cell-types in the complex microenvironment of the inflamed synovium. The ‘synovium’ is a multicellular tissue, with cells differing in their metabolic requirements depending on complex cell-cell interactions, nutrient supply, metabolic intermediates, and transcriptional regulation. In this adverse synovial microenvironment both immune and stromal cells adapt their metabolic profiles in
order to generate sufficient energy to support their highly activated inflammatory state. Thus, understanding the complex interplay between metabolic and inflammatory pathways in synovial cells from patients with specific pathotypes will provide significant insight into the underlying mechanisms of disease pathogenesis. Thus, the current project focuses on identifying the cellular, molecular and metabolic mechanisms that differentiate RA and PsA pathogenesis. We will utilise a combination of well-established in vitro and ex vivo tissue/cell 2D/3D culture models, along with metabolic, molecular, VISIUM spatial-RNAseq and non-invasive imaging analysis to examine immune-stromal cell Interactions, and how this may differ between RA and PsA. This project utilises a multidisciplinary approach combining expertise in molecular biology, cell biology and bioengineering, applied to cell
and tissue obtained from well-defined patient cohorts
To Apply: The candidate should apply directly to WADESI@tcd.ie along with a detailed CV and cover note.. Informal Enquiries can be directed to Prof Ursula Fearon (email@example.com)
Status: Accepting applications.
Tenure: Specified purpose contract for up to 3 years.
Deadline: 4th March 2022