Post-Doctoral Fellow and PhD Studentship positions in Molecular Rheumatology, Trinity College Dublin




Post Summary: Molecular Rheumatology, Trinity Biomedical Sciences Institute, TCD (https://rheumatologytcd.com) is seeking to appoint a Post-Doctoral Fellow (3 years) and a PhD student (4 years), funded by Science Foundation Ireland, to perform research focused on the identification of molecular signatures that distinguish RA and PsA pathotypes - impact for disease progression and response.


Project Description:

Inflammatory arthritis are chronic autoimmune diseases. Two of the most common forms of inflammatory arthritis (IA) are rheumatoid arthritis (RA) and psoriatic arthritis (PsA) with peak onset of disease between 35-45 years of age. The pathogenesis of IA involves complex

cellular interactions and networks of various cytokines that trigger the synovium to transform into a ‘tumor-like’ pannus, which invades both cartilage and bone, resulting in functional disability. Common pathogenic features exist between RA and PsA, however significant differences are observed at the clinical, immunological, cellular and molecular level. While some synthetic and biological DMARDs are effective in both patient groups, different responses have been demonstrated to new targeted therapies.


At a molecular single-cell level, little is known about the distinct underlying mechanisms involved in driving this differential pathogenesis in the target tissue of disease ‘the synovium’, with most studies restricted to histological analysis, which has failed to provide solutions. In this project, using extensive primary cell culture, molecular analysis, scRNAseq, VISIUM spatial-RNAseq, non-invasive imaging analysis, along with extensive mechanistic studies using 2D/3D culture models, we will dissect the distinct molecular signatures involved in driving differential monocyte and macrophage pathogenic

mechanisms in RA and PsA to define (i) differential pathogenic mechanisms and (ii) identify new targets for novel therapeutic strategies. This project utilises a multidisciplinary approach combining expertise in molecular biology, cell biology and bioengineering, applied to cell and tissue obtained from well-defined patient cohorts, thus will contribute to our basic knowledge of the disease pathogenesis.


Informal enquiries to Prof Ursula Fearon, fearonu@tcd.ie, Molecular Rheumatology, TCD (https://rheumatologytcd.com).


To Apply: The candidate should apply directly to WADESI@tcd.ie along with a detailed CV and cover note.

Status: Accepting applications.

Deadline: 1st December 2021


For more information see below document.

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