PhD studentship: Immunophenotyping pancreatic cystic lesions for cancer stratification.

Post Summary

Primary supervisor: Dr. Joanne Lysaght

Co-supervisor: Dr. Stephen Maher

Dr. Joanne Lysaght leads the Cancer Immunology and Immunotherapy Group in the Department of Surgery, Trinity Translational Medicine Institute (TTMI), School of Medicine at Trinity College Dublin and the Trinity St. James’s Cancer Institute. Dr. Stephen Maher leads the Cancer Chemoradiation Research Group in TTMI. This project will be conducted in collaboration with Prof. Barbara Ryan, a gastroenterologist and clinical lead at Tallaght University Hospital. The successful applicant will work within a multidisciplinary team, including clinical and non-clinical PIs, postdoctoral research fellows and postgraduate researchers at TTMI, which is based on the St. James’s Hospital campus in Dublin. This translational cancer project forms part of larger research programme identifying biomarkers in pancreatic cyst lesion (PCL) fluid that delineate pre-cancerous intraductal pancreatic mucinous neoplasms (IPMNs) from benign PCLs. Project Description: The overall aim of this project is to determine if low- and high-risk IPMN cyst fluid differentially promotes immunosuppression and subsequent risk of malignant progression. The successful candidate will characterise the immune cell infiltrate and immunomodulatory secretome of high- and low-risk PCL cyst fluid for risk stratification and investigate its influence on anti-tumour cytotoxic T cell function.

Starting Date: 1st September 2021. This position is supported by Trinity College Dublin’s Provosts PhD Project Awards, covering fees (either EU or Non-EU) plus an annual stipend of €17,316 per year for 4 years. These doctoral awards are generously funded through alumni donations and Trinity’s Commercial Revenue Unit.

Status: Accepting applications.

Deadline: 5pm (GMT) 2nd July 2021.

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Pancreatic PhD Position 2.7.21
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