Glucose drives tuberculosis vaccine responses offering hope for improved efficacy

The work led by Prof. Mary O'Sullivan, funded by the Health Research Board and the Royal City of Dublin Hospital Trust, sheds light on how human CD1c+ myeloid dendritic cells change their metabolism upon encountering the BCG vaccine and how this impacts their function. The scientists in the TB Immunology group at Trinity College Dublin and St. James's Hospital have provided fresh insights into the key role of glucose metabolism in how these cells deal with infection by BCG.

Read the press release by Trinity College here and orignal article at the publisher's website by clicking this link.