• Prof. Luke O’Neill

    Trinity College Dublin, Ireland

    Prof. O’Neill’s webpage

    Research interests: The major focus of the group is to provide a molecular understanding of innate immunity and inflammation. We are interested in receptors involved in innate immunity, such as Toll-like receptors (TLRs) and Nod-like receptors (NLRs – including Nlrp3), and also signals activated. The role played by this system in inflammatory diseases is also under investigation. We have several projects underway including:

    • Control of the NLRP3 inflammasome
    • Regulation of the TLR adapter Mal
    • Examining intracellular metabolism and metabolic reprogramming in innate immunity and inflammation
    • Circadian control of innate immunity